Incidence of myocarditis/pericarditis following mRNA COVID-19 vaccination among children, younger adults in the US

Incidence of myocarditis/pericarditis following mRNA COVID-19 vaccination among children, younger adults in the US


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In a population-based surveillance printed within the Annals of Inner Medication, the authors discovered that myocarditis/pericarditis zero to 7 days after mRNA vaccination in individuals aged 5 to 39 years occurred in roughly 1 in 200,000 doses after the primary dose and 1 in 30,000 doses after the second dose of the first collection, and 1 in 50,000 doses after the primary booster. The incidence diverse markedly by age and intercourse, nonetheless, with a disproportionate variety of instances occurring in male individuals, notably amongst adolescents after dose 2 and first boosters.

The authors noticed incidence after first boosters was typically increased than after dose 1, in keeping with reporting from Israel. Nevertheless, in distinction to this earlier report, they didn’t persistently observe a decrease incidence after the primary booster than after the second dose within the main vaccination collection. Incidence charges of myocarditis/pericarditis noticed within the VSD inhabitants had been increased, notably after first boosters, than these reported to the U.S. Vaccine Hostile Occasion Reporting System (VAERS), however patterns famous by intercourse and age subgroups had been related.

Charges within the VAERS report could also be decrease due to the passive nature of VAERS reporting versus VSD’s identification of instances utilizing lively surveillance. Each VSD and VAERS discovered incidence charges throughout days zero to 7 after vaccination that had been increased than the pre-pandemic background charges famous by Oster and colleagues; nonetheless, pre-pandemic charges might not be instantly comparable with publish vaccination charges as a result of underdiagnosis of myocarditis/pericarditis on this age vary was extra doubtless pre-pandemic than publish vaccination when surveillance was larger.

Hostile reactions to BNT162b2 delicate, reasonable for 5- to 11-year-olds

Extra info:
Kristin Goddard et al, Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Amongst Youngsters and Youthful Adults in the USA, Annals of Inner Medication (2022), DOI: 10.7326/M22-2274.

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American School of Physicians

Incidence of myocarditis/pericarditis following mRNA COVID-19 vaccination amongst kids, youthful adults within the US (2022, October 3)
retrieved Three October 2022

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